Tuesday's 88th Major League Baseball All-Star game was the first since 2002 in which home field advantage in the World Series was not awarded to the winning league.
At 34, the Seattle second baseman was among the oldest players in an event built around so numerous sport's new, young stars, and he was added to the roster only Friday as an injury replacement.
It was the first extra-inning home run in an All-Star Game since Tony Perez hit one exactly 50 years ago - July 11, 1967.
When Josh Harrison looked around the National League clubhouse at Tuesday's All-Star Game in Marlins Park, he didn't see many faces that looked like his.
One such moment occurred in the sixth inning, when Mariners star Nelson Cruz took out his phone before reaching the batters box and requested a picture with veteran umpire Joe West. Cruz had hoped to take a selfie with the ump but was hindered by his batting gloves, leading catcher Yadier Molina to play the role of photographer.
Kimbrel, throwing at up to 100 miles per hour, stranded runners at second and third to end the ninth, striking out Michael Conforto. Cleveland's Andrew Miller got the save, striking out Cody Bellinger to end it.
The American League grabbed a 1-0 lead in the fifth inning.
Thanks in part to Cano, the AL won its fifth straight All-Star Game and tied the all-time series 43-43-2. Harrison was one of just two players with African-American heritage in the National League clubhouse along with the Marlins' Giancarlo Stanton.
Major League Baseball made significant changes to the annual all-star game, most notably detaching the home field advantage in the World Series from the victor of the event. Instead, the American League winners get $20,000 apiece, while the losers get nothing.
Cano enjoyed watching the moment from the AL dugout after being tipped off by Cruz prior to the game. NL starter Max Scherzer also came out letting it fly.
"When else are you ever going to get a chance to take a picture with an umpire except at the All-Star Game?" the 37-year-old Cruz said with a smile. AL pitchers fanned nine.
"Winning MVP, you want to get that feeling", Cano said.
Harper made a great play in the second inning, robbing Salvador Perez of a single to shallow right-center. Betances joined Juan Marichal, Dave Stieb and John Smoltz as the only ones to throw two wild pitches in an All-Star inning.
"I don't need anything on the line", Scherzer said.